BellBrook’s AptaFluor® assay platform leverages the power of aptamers to accelerate drug discovery. The new AptaFluor SAH Methyltransferase Assay uses a novel split aptamer approach with a TR-FRET readout to measure methyltransferase enzyme activity. Future assays will employ a variety of detection strategies to provide robust, easy to use homogeneous assays for drug discovery.
The AptaFluor SAH Methyltransferase Assay uses an aptamer that selectively binds with the SAH, the product of methyltransferase reactions. The exquisite affinity and selectivity of the riboswitch combined with a positive TR-FRET signal enable screening and profiling of histone methyltransferases with unparalleled sensitivity.
“Some CROs reserve their best teams for high profile customers. If you’re not right there with them you get less experienced teams… BellBrook understands enzyme kinetics, so it made that part of the project so much easier. The larger CRO didn’t seem to have the expertise we needed in this area.”
“The ADP assay is a great choice for measuring activity for any ADP-generating enzyme in both real time and endpoint formats. The universal detection system has been very useful for more challenging targets.”
“Excellent blend of simplicity & good science. Excellent technical support”
“The assay itself has good reproducibility and provides a clear readout on our enzyme activity. The most important piece, however, is the level of attention to our project and rapid turnaround time. The staff at BellBrook knows what they are doing.”
“The Transcreener AMP/GMP Assay is extremely straightforward to use and is very sensitive. In a UV-based enzyme assay I needed 1 µM enzyme to see a decent signal; however using the Transcreener AMP assay I only need 10 nM. Also, BellBrook Labs have been very helpful with the assay development. Their representative has been very willing to quickly help me get my assay up and running.”
“Through the process of developing and validating an assay for HTS applications, I generated a very nice data package of robust high quality data.”
BellBrook Labs
1232 Fourier Drive, Suite 115
Madison, Wisconsin 53717 USA
(608) 443-2400
info@bellbrooklabs.com
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