BellBrook Labs
1232 Fourier Drive, Suite 115
Madison, Wisconsin 53717 USA
(608) 443-2400
info@bellbrooklabs.com
Poly(ADP-ribose) polymerases (PARPs) are central to DNA damage repair, and selective inhibition has emerged as a powerful synthetic lethality strategy. PARP inhibitors have already transformed the treatment of BRCA1/2-mutant cancers and continue to expand into breast, ovarian, prostate, and pancreatic indications. To accelerate the discovery of next-generation PARP inhibitors, BellBrook Labs has developed a robust, […]
Selective inhibition of VPS4A and/or VPS4B represents a promising synthetic lethality approach in oncology. However, achieving specificity without affecting related ATPases remains a major challenge. Join us for this webinar to explore how BellBrook Labs has developed a robust high-throughput assay for VPS4A/VPS4B ATPase activity—enabling efficient screening and structure-activity relationship (SAR) optimization for potential anticancer […]
Membrane-associated tyrosine and threonine-specific cdc2-inhibitory kinase (PKMYT1 or MYT1) is a member of the WEE1 family of CDK1 (cdc2) phosphorylating inhibitors. Both WEE1 and PKMYT1 act on CDK1 to prevent premature entry into M-phase, if detectable levels of DNA damage exist. PKMYT1 plays a similar role in meiotic regulation. While WEE1 functions primarily in the […]
KMT2B (Lysine [K] Methyltransferase 2B) or Mixed Lineage Leukemia 2 protein (MLL2) is a mammalian histone H3 lysine 4 (H3K4) methyltransferase. It readily forms complexes with WRAD, host cell factors 1 and 2, and Menin. These complexes confer H3K4 trimethylation to specific gene promoters and some enhancers to regulate bivalent developmental genes and stem cell/germ […]
DDX17 (p72/p82) was first detected as a bunyavirus inhibitor. Subsequent characterization revealed that it is an ATP-dependent RNA helicase, belonging to the DEAD-box group of proteins and bearing the signature Asp-Glu-Ala-Asp sequence. The presence of a novel upstream CTG translation start site (in addition to a conventional ATG start site) produces two isoforms: p72 is […]
DNA methyltransferase 3-alpha (DNMT3A) effects de novo cytosine methylation in embryonic and somatic cells through the transfer of a methyl group from S-Adenosyl-L-methionine (SAM) to the cytosine-C5 position of newly created CpG DNA residues. In somatic cells, 60 to 80% of these structures are methylated at any given time. Nonetheless, clusters of CpG residues (islands) […]
Methyltransferase-like 3 (METTL3) is a 70 kDa protein, 580 amino acids in length. It is the principal catalytic agent for most of the N6– methyladenosine (m6A) modifications that occur in eukaryotic cell mRNA. METTL3 typically places methyl adducts at the adenosine in motifs, such as DRACH, RAC, or RRACH. As such, it influences mRNA splicing, […]
Methyltransferase-like protein 16 (METTL16) is a recently characterized human RNA methyltransferase in the class I SAM-methyltransferase family. It methylates adenosine at the N6 position in a consensus sequence on U6 small nuclear RNA (U6 snRNA) and S-adenosylmethionine (SAM) synthetase (MAT2A) pre-mRNA to control the activity of these molecules. By regulating SAM homeostasis in a feedback […]