TL;DR: Pick a biochemical assay development CRO that (1) understands your enzyme target and can source/produce active protein, (2) aligns on assay goals and screening scale, (3) has proven assay technology expertise and can meet Z′ and sensitivity needs, (4) can build custom assays when universal formats fall short, and (5) offers the right size, […]
Identifying bona fide hits efficiently and effectively is a challenge in any small molecule drug discovery program. Using the appropriate assays for screening and hit-to-lead is an important determinant of success, but choosing from among the myriad types of assays can be a daunting process. ADP detection simplifies discovery, providing a universal approach to targeting […]
Increased instrumentation costs and limited budgets mean that most HTS labs rely on a single type of multimode plate reader, which may limit the detection modes that can be used. The ability of an assay technology to generate different types of readouts and perform well on a variety of plate readers is certainly an asset […]
Glycosyltransferase (GT) enzymes participate in diverse metabolic and regulatory roles by catalyzing the transfer of sugars to protein, lipid and carbohydrate acceptors as well as to other molecules. Within the GT family, there are over 20 distinct polypeptide N-acetylgalactosaminyltransferases (GALNTs) that catalyze the initial step of O-glycosylation. GALNT3 overexpression and dysregulation has been directly linked […]
BellBrook Labs
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