BellBrook Labs is a small, custom shop. We are able to customize assay conditions as needed to suit a project’s requirements and run compounds as soon as we receive them here in our lab in Madison, WI, providing faster results for your program. The best part – you will collaborate directly with a BellBrook scientist, who are experts in biochemistry and enzymology.
Our Transcreener ADP2 Assay is an extensively validated technology that has been used in millions of wells by large pharma. It is based on a novel direct ADP detection method that reduces compound interference and the risk of false positives in a screen.
Heliscreener RNA Unwinding Assay is designed to measure the unwinding activity of RNA Helicases. Either or both assays can be performed for screening or Hit-to-Lead campaigns.
Interested in our helicase profiling services? Contact a BellBrook Scientist:
Helicase profiling is available for the enzyme targets listed in the table below. Click on a target to learn more. We continue to develop assays for new helicase targets all the time. If you don’t see your target listed, please inquire. We may still have experience with that target and can develop an assay that will advance your program needs.
Examples of Dose Response Curves using Transcreener’s ADP Assay.
Examples of Dose Response Curves using the Heliscreener RNA Unwinding Assay.
Leveraging BellBrook’s services expertise will save you time and money. Your project will be handled by the same BellBrook scientists who developed the Transcreener assay and have optimized them for more than 100 different enzymes, including helicases, kinases, ATPases, GTPases, glycosyltransferases, ligases/synthetases, and phosphodiesterases. We will tailor our efforts to meet your specific needs. For example, minimizing consumption of limited reagents or enabling simultaneous screening for inhibitors and activators. And we will work fast. If your target enzyme is listed here, we can generally complete the services within one to two weeks.
There is extensive crosstalk between the DNA damage response (DDR) pathways and innate immune pathways. Both the individual pathways and the interconnections between them are a focus for exciting new small molecule drug therapeutics that target cancers and debilitating autoimmune disorders. The Transcreener HTS Assay platform accelerates these efforts by providing a robust and easy-to-use biochemical assay to measure activity of key enzymes in the innate immune and DDR pathway.
In this guide, we provide an overview of the DDR and innate immune pathway, and describe Transcreener Assays and Assay Systems for key therapeutic targets. The enzyme targets discussed include:
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BellBrook Labs
1232 Fourier Drive, Suite 115
Madison, Wisconsin 53717 USA
(608) 443-2400
info@bellbrooklabs.com
