New! Simpler, More User-Friendly Transcreener EPIGEN Methyltransferase Assay

Methyltransferases are key players in epigenetic control of gene expression and have become the targets of intensive public and private drug discovery efforts.  To accelerate these efforts, BellBrook developed the Transcreener EPIGEN Methyltransferase Assay, a fluorescent SAH detection assay with the sensitivity needed to detect any methyltransferase at physiological SAM concentrations, and the robustness required for industrial HTS.  Since its introduction in 2011, the EPIGEN assay has been validated on all of the major instrument platforms and adopted by industrial and academic laboratories worldwide.  Now, in response to customer feedback, we have reduced the number of components and simplified the protocol.  The performance and response of the simplified assay is identical to the original kit; it contains pre-mixed detection components, so assay set-up is simpler and results are more reproducible. 

For more information on the improved assay, see the Transcreener EPIGEN Methyltransferase Assay page.

Learn more about the development of the EPIGEN MT assay in this JBS paper.