Recombinant cGAS Enzyme, Mouse, Full-Length

Active, full-length Mouse Cyclic GMP-AMP synthase enzyme, His-tagged protein expressed and purified from E.coli. The enzyme has been thoroughly validated with Transcreener cGAS Activity Assays. For specific activity, please refer to the Certificate of Analysis for each individual enzyme lot. Purity is >79% in a 10mM Tris 8.0, 50mM NaCl, 1mM TCEP buffer composition.

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Alternate Names

Cyclic GMP-AMP synthase
cGAMP synthase
m-cGAS
2’3’-cGAMP synthase
Mab-21 domain-containing protein 1
C6orf150

Storage Information

Store at -80ºC.
Avoid freeze-thaws.
Stable for up to 6 months from date of receipt.

Recombinant Mouse cGAS Enzyme

Name: Recombinant cGAS Enzyme, Mouse, Full-Length
SKU: 21458
Availability: InStock

Certificates of Analysis

Cat. No. 2239 – 10 μg Mouse cGAS Enzyme

C of A for Lot# 13943B C of A for Lot# 14728 C of A for Lot# 14809 C of A for Lot# 14976

Cat. No. 2300 – 100 μg Mouse cGAS Enzyme

C of A for Lot# 13943G C of A for Lot# 14728 C of A for Lot# 14809 C of A for Lot# 14976

Learn More About Targeting the cGAS-STING Pathway Using the cGAS Enzyme in This Poster from BellBrook Labs.

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cGAS Enzyme Has an Important Role in the STING Pathway

When free DNA is in the cytoplasm of eukaryotic cells, it can be an indication of damage or infection to the cell. This DNA triggers an immune response led by type I interferon (IFN) production. The cGAS enzyme acts as a unique sensor for double-stranded DNA. When DNA binds to cGAS it activates the enzyme producing a dinucleotide cGAMP from ATP and GTP. cGAMP created by cGAS activates STING (stimulator of interferon genes), leading to IFN immune response in the cell.

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“Some CROs reserve their best teams for high profile customers. If you’re not right there with them you get less experienced teams… BellBrook understands enzyme kinetics, so it made that part of the project so much easier. The larger CRO didn’t seem to have the expertise we needed in this area.”

- BioPharma Lead Discovery Program Manager

“The ADP assay is a great choice for measuring activity for any ADP-generating enzyme in both real time and endpoint formats. The universal detection system has been very useful for more challenging targets.”

- Pharmaceutical Research Scientist

“Excellent blend of simplicity & good science. Excellent technical support”

- Director Pharma Drug Discovery Center

“The assay itself has good reproducibility and provides a clear readout on our enzyme activity. The most important piece, however, is the level of attention to our project and rapid turnaround time. The staff at BellBrook Know what they are doing.”

- Biotech Program Manager

“The Transcreener AMP/GMP Assay is extremely straightforward to use and is very sensitive. In a UV-based enzyme assay I needed 1 µM enzyme to see a decent signal; however using the Transcreener AMP assay I only need 10 nM. Also, BellBrook Labs have been very helpful with the assay development. Their representative has been very willing to quickly help me get my assay up and running.”

- University Research Scientist

“Through the process of developing and validating an assay for HTS applications, I generated a very nice data package of robust high quality data.”

- Biotech Research Scientist

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