Start Your Screening Program

with Confidence

Get your assay working the way it should—before you commit to screening.

We help teams design and optimize assays that deliver clean signal, reduce triaging, and scale efficiently to HTS. Work directly with our scientists to move from setup to screening faster, with fewer surprises along the way.

Planning a screen? Talk to a scientist.

Who It’s For

Scientists preparing for a screening campaign
Teams optimizing assays for HTS
Groups scaling to 384- or 1536-well formats
CROs supporting multiple screening programs
Groups doing SAR and mechanistic studies
Confirming hits from a virtual screen

Kinase Activity Assay Pipetting In the Lab

Microplate experiment data analysis workflow

Why Screening Programs Fail

Most screening challenges come from assay design—not execution.

Common issues include:

Low Z′ and poor assay robustness
High false positive rates
Assays that don’t scale to HTS
Excessive reagent consumption
Difficult transfer to automation

These problems lead to rework, delays, and increased cost.

Download Our HTS Screening Optimization Guide

How to Run a Successful HTS Screening Campaign Thumbnail

If you’re still evaluating assay approaches or planning a screening campaign, this guide will help you:

Choose the right assay format
Improve Z′ and assay robustness
Reduce false positives
Scale to 384- and 1536-well formats
Control reagent cost

No commitment. Practical, workflow-focused guidance.

How to Start a Successful Screening Program

Choose the Right Assay Format
- Match assay type to screening goals
- Minimize interference and complexity
- Choose the best fluorescent readout
Optimize for Robustness and Sensitivity
- Strong Z′
- Consistent signal window
- Reproducibility across plates
Design for Scale Early
- Validate at 384 and 1536
- Ensure compatibility with automation
- Plate reader implementation
Reduce False Positives Upfront
- Simplify assay system
- Avoid unnecessary coupling steps
Control Cost Without Sacrificing Data
- Optimize reagent usage
- Reduce rework and repeats
- Triage more efficiently

Where BellBrook Fits

We help teams move from assay setup to screening with:

Robust, HTS-Ready Assays

Designed for reproducibility and scalability

Direct Detection of Enzymatic Products

Measure ADP, GDP, AMP directly
Use native substrates without modification
Flexible across enzyme classes

Simplified Workflows

Fewer components
Reduced variability
Easier automation

Lower Total Screening Cost

Reduced reagent consumption
Fewer repeat experiments
Scalable to large campaigns

Flexible Support Options

Assay selection
Optimization
Troubleshooting

See What Other Scientists Are Saying About Transcreener.

“The ADP assay is a great choice for measuring activity for any ADP-generating enzyme in both real time and endpoint formats. The universal detection system has been very useful for more challenging targets.”

- Pharmaceutical Research Scientist

“We were struggling with a narrow assay window and poor sensitivity with luciferase-coupled ATPase assays. Initially, we had Bellbrook run their Transcreener ATPase assay in-house as a contracted project. We were so pleased with the results that we immediately onboarded the assay to our company lab. Throughout the whole process, Bellbrook scientists were clear, rapid communicators and demonstrated their deep knowledge of the assay. We highly recommend Bellbrook to our peers in drug discovery.”

- Biotech Research Scientist

“Excellent blend of simplicity & good science. Excellent technical support”

- Director Pharma Drug Discovery Center

“The assay itself has good reproducibility and provides a clear readout on our enzyme activity. The most important piece, however, is the level of attention to our project and rapid turnaround time. The staff at BellBrook knows what they are doing.”

- Biotech Program Manager

“Through the process of developing and validating an assay for HTS applications, I generated a very nice data package of robust high quality data.”

- Biotech Research Scientist

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Two Ways to Get Started

Option 1: Talk to Our Team

Best if you are:

planning a screening campaign
confirming hits from a AI screen
comparing assay formats

Talk to A Scientist

Option 2: Start with an Evaluation Kit

Best if you:

want to test performance in your system
are interested in direct detection or kinetic mode
getting ready for SAR or profiling

Get A Kit Today

Not Ready Yet? – Download Our HTS Screening Optimization Guide

If you’re still evaluating assay approaches or planning a screening campaign, this guide will help you:

choose the right assay format
improve Z′ and assay robustness
reduce false positives
scale to 384- and 1536-well formats
control reagent cost

No commitment. Practical, workflow-focused guidance.

Want to Screen Smarter?

Get A FREE Evaluation Kit and/or Consult with A Scientist

Please fill out the form below. We will respond quickly to get the conversation moving and learn how we can help. We keep things discrete, confidential, and professional.

We understand that confidentiality in this business is critical. Our goal is to accelerate your discovery by providing the best assay available, coupled with expert support. Trials are limited. The project must qualify for a free evaluation. BellBrook Labs reserves the right to provide evaluation kits as directed.