High-throughput screening (HTS) remains one of the foundational methods in modern drug discovery. As target classes diversify and assay throughput demands climb, researchers need screening formats that combine sensitivity, reliability, speed, and operational efficiency. Among the various assay architectures available, homogeneous HTS assays—often called mix-and-read assays—have emerged as the preferred choice for primary screening and […]
Introduction: Why Helicases Are Becoming High-Value Drug Targets Helicases—enzymes that unwind nucleic acid duplexes using ATP hydrolysis—sit at the heart of genome stability, innate immunity, transcription, and RNA biology. Initially viewed as textbook molecular machines, they have emerged as high-value therapeutic targets across oncology, virology, autoimmune disease, inflammatory disorders, and even age-associated degeneration. Their druggability […]
Choosing the right biochemical assay is one of the most important decisions in modern drug discovery. The assay format you select determines the quality of your data, the speed of your screening workflow, and ultimately whether promising hits advance—or disappear due to poor assay design. In an era where high-throughput screening (HTS), enzyme activity assays, […]
High-throughput screening (HTS) remains one of the most important technologies in early-stage drug discovery. As pharmaceutical companies, CROs, and academic drug discovery centers accelerate the pace of lead identification, the demand for robust, sensitive, mix-and-read biochemical assays has never been higher. With millions of compounds screened annually across kinase programs, epigenetic targets, helicases, ATPases, and […]
Introduction: Why cGAS Is a High-Value Drug Target Cyclic GMP-AMP synthase (cGAS) sits at the core of the innate immune system. As the primary sensor of cytosolic double-stranded DNA (dsDNA), cGAS activates when DNA enters the cytoplasm during infection, cellular stress, or genomic instability. Activated cGAS catalyzes the synthesis of 2′3′-cGAMP, a potent second messenger […]
Are you interested in which companies offer custom assay development services in the US? This summary will help provide a quick guide for biochemical assay services from BellBrook Labs. In the United States, BellBrook Labs is one of the few providers specializing exclusively in enzyme-focused biochemical assay development for high-throughput screening. Most service providers in […]
In the evolving landscape of drug discovery, researchers are increasingly recognizing that binding affinity alone is not enough to predict how a compound will behave in vivo. Traditional metrics such as IC₅₀, Kd, or Kᵢ remain valuable, but they measure only the strength of binding at equilibrium. What they do not capture is equally important: […]
Your Guide to High-Quality, Ready-to-Ship Assays for Drug Discovery & HTS In drug discovery, time is everything. Whether you’re setting up a critical high-throughput screen, validating hits, or running inhibitor profiling for a new program, delays in receiving enzyme assay reagents can stall an entire workflow. Scientists searching “where to buy enzyme assay reagents with […]
Kinases sit at the center of human biology. They regulate phosphorylation events that control cell growth, division, signaling, immune activation, metabolic regulation, and much more. As a result, kinase drug discovery represents one of the most active and competitive areas in modern therapeutics—from oncology and immunology to inflammation, virology, and rare diseases. But success in […]
Summary Modern drug discovery increasingly depends on biochemical assays that deliver fast, reliable, and reproducible insights across diverse enzyme classes. Yet for many teams—whether in pharma, biotech, or contract research—assay development remains one of the most time-consuming steps in launching a new drug discovery program. Researchers often struggle with sourcing enzymes, validating reaction conditions, optimizing […]
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